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KMID : 1098420070150060437
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 6 p.437 ~ p.443
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Modulation of Cytochrome P-450 Induction by Long-Term Supplementation with Korean Red Ginseng to Rats
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Lim Heung-Bin
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Abstract
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This study was carried out to investigate the effect of dietary supplementation with red ginseng water-extracts on the induction of microsomal cytochrome P-450 in rats. Phenobarbital (PB) and 3-methylcholanthrene (3-MC), P-450 inducers, were administered to 3- or 12-month old rats received red ginseng extracts (25 mg/kg) from 6 weeks to 12 months for 3 days. PB and 3-MC increased levels of P-450, P-450 reductase, ethoxycoumarin O-deethylase, benzphetamine N-demethylase and glutathione-S-transferase in the liver of rats. However, chronic administration of red ginseng significantly reduced these increase of enzyme levels induced by P-450 inducers. Chronic administration of red ginseng did not affect the induction of cytochrome and NADH cytochrome reductase by P-450 inducers. It is suggested that the induction of cytochrome P-450 system in the liver in relation to xenobiotics toxicity can be modulated by long-term supplementation with Korean red ginseng to rats.
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KEYWORD
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red ginseng, enzyme induction, cytochrome P-450 inducers
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